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25 ноября 2022
DSTU DEVELOPED AN ARTIFICIAL GASTROINTESTINAL TRACT (GIT) OF ANIMALS
Scientists of Don State Technical University have created a bioreactor that reproduces the animals gastrointestinal tract.
The artificial gastrointestinal tract, which has no analogues in the Russian Federation, will significantly increase the effectiveness of preclinical studies of pharmacological preparations and dietary supplements. The installation is used to study the effect of pharmacological preparations, food and bioactive additives, in particular prebiotics, on the microbiota of animals and the pharmacokinetics of preparations under gastrointestinal conditions.
The unique scientific installation was developed under the guidance of Alexander Lukyanov, head of the DSTU Automation Department with the participation of two members of the department – the 1st year postgraduate student Danil Donskoy and the 3rd year postgraduate student Miroslav Vernezi.
The installation will make it possible to check the safety and effectiveness of pharmacological preparations and food additives for the gastrointestinal tract of animals at the early stages of development. The installation enables to determine quickly the effectiveness of the tested drugs and additives, and clinical studies in animals can be carried out only with drugs that have passed the preclinical stage and are completely safe for their gastrointestinal tract. In addition, the development will reduce the financial and organizational issues on clinical trials.
According to the project manager, the uniqueness of the development is that there are no such models capable of reproducing physiological, biochemical and microbiological parameters of the gastrointestinal tract of animals in Russia. The important advantage of the development is that it is a patented model of artificial gastrointestinal tract of animals (9 patents are registered totally). Moreover it is built on a modular principle, which allows reproducing the gastrointestinal tract of different animals: dogs, cats, chicken, pigs, in which it differs in length, acidity in different departments, as well as in anatomical features.
Now the installation is used to conduct research simulating chicken and dogs. At the next stage, the scientists plan to adjust the modules and adapt them for human gastrointestinal research.
The research is carried out at the expense of the mega-grant of the Government of the Russian Federation No. 220 for 2019-2021 (the term for the implementation of the mega-grant has been extended until the end of 2023) under the leadership of Mikhail Chikindas, a visiting scientist - professor at Rutgers University (USA, New Jersey).